Intra-surgical MRI

In Collaboration with 

Pre-surgical MRI is commonly used to provide an anatomical reference for navigation during open-brain surgery. By doing so, it is implicitly assumed that brain remains immobile with regard to the skull during surgery. In practice, this assumption has only a limited validity in time. When the skull is opened, at the beginning of surgery, Cerebrospinal fluid leaks out causing the brain to drift progressively with regard to the skull. This well known effect is  called the brainshift.

Low field intra-surgical MRI (iMRI), as  pioneered by Sheba's neurosurgery department, provides updated MRI images during surgery, thereby helping to compensate for brainshift. In practice, however, due to magnetic field and physical size limitations, iMRI cannot provide images with comparable SNR and resolution  as the pre-surgical images obtained on a full size, high field scanner.

The goal of this project is to develop an accurate and robust registration algorithm between high quality pre-surgical MRI and noisy iMRI images. Eventually, after successful registration is reached,  functional and DTI tractography maps will be projected from the pre-surgical image space to the iMRI space, as shown in the initial results presented in fig. 1

                                                               Fig. 1 Initial result for the alignment of pre-surgical MRI and iMRI 



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